Titlebook: Advanced Intelligent Computing in Bioinformatics; 20th International C De-Shuang Huang,Yijie Pan,Qinhu Zhang Conference proceedings 2024 Th

漂亮

Biotechnologie und Umweltmikrobiologie,gh dynamic programming. MSA is a crucial tool for temporal analyses such as classification, aggregation, and speech recognition. The process uses a penalty score to assess the similarity among the sequences, with or without gaps. In bioinformatics, MSA is widely used to identify conserved regions an

Deject

,Mikrobielle Ökologie und Biogeochemie,ositioning can reduce experimental costs and expedite drug development. In this paper, a knowledge graph is employed to integrate biological data from various database sources. Subsequently, a graph embedding algorithm based on random walks is utilized to obtain feature vectors of entities in the gr

挥舞

,Mikrobielle Ökologie und Biogeochemie,e performance, they are seldom applied in medical recommendations due to their lack of interpretability. On the other hand, traditional statistical methods are easily interpretable but often limit in performance. In this study, we propose a novel framework called Diagnosis Neural Collaborative Filte

在前面

,Mikrobielle Ökologie und Biogeochemie,get is unavailable. This paper proposed a drug design model based on the protein sequence features. The model utilizes Transformer and a graph neural network (GNN) algorithm based on the weighted protein graph to obtain protein sequence features. This approach allows model to effectively understand

牵索

Biotechnologie und Umweltmikrobiologie,drug development. Various sequence-based and graph-based deep learning models have achieved good performance in drug target affinity (DTA) prediction, but most of them extract features at a single scale, and this approach is deficient in global topological feature extraction. In this paper, we propo

来就得意

https://doi.org/10.1007/978-3-642-05096-1nsuming and expensive. Therefore, deep learning-based methods have been widely applied in the field of DTIs prediction. In recent years, methods utilizing graph convolutional neural networks to learn the features of drug-protein pairs (DPPs) and thus achieve DTI prediction have achieved certain succ

闯入

,Mikrobielle Ökologie und Biogeochemie,cRNAs regulate gene expression by adsorbing miRNAs and acting as ‘sponges’. Dysregulation of miRNAs has been observed in various cancer tissues, and co-expression of circRNAs with miRNAs has been noted in many cancer tissues. The co-expression of miRNAs with circRNAs may play an important role in re

GROSS

排斥

Flatter

Biotechnologie und Umweltmikrobiologie,owever, existing deep learning approaches face a challenge due to the lack of representations for non-pairwise relations and substructures in compounds, leading to limited performance and poor generalization ability. To address this challenge, a novel method named HyperCPI is proposed in this study.