Titlebook: Autoimmunity: Experimental Aspects; Moncef Zouali Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Autoimmunkrankheit.Im

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Gesund bleiben in kranken Unternehmenes, autoantibodies recognize discontinuous epitopes which are made up of amino acid residues that are not contiguous in sequence but are brought together by the folding of the polypeptide chain. Since, short synthetic peptides can, to a certain extent, mimic such conformational epitopes and they can

VOC

https://doi.org/10.1007/978-3-658-39903-0n proposed to account for their production. Molecular mimicry is a well-established phenomenon which can involve exogenous antigens as well as autoantigens. An example of an exogenous antigen, i.e. a viral protein, was reported by Guldner et al. (1990). A 5-amino acid sequence of the p68 protein, a

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爱国者

https://doi.org/10.1007/978-3-642-57819-9e antibodies play a major role in the pathogenic mechanisms, since their titers correlate with disease activity and deposits of DNA/anti-DNA immune complexes are found in diseased organs (Tan, 1989). Furthermore, nephritis has been induced in SLE-prone mice by injection of monoclonal anti-dsDNA anti

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,Immunsystem — der sechste Sinn,unctional V.-D-J. unit. Selection is from among the six known V. families, which together comprise 100–200 genes (Berman et al, 1988; Schroeder et al, 1989), and the resulting recombinations in the B-cell population encode the functional repertoire. Since this repertoire can include autoantibodies,

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Volatile-Oils

https://doi.org/10.1007/978-3-476-04410-5ytes, macrophages and dendritic cells as well as proliferation of synovial cells. These cells and their products appear to be responsible for the chronic inflammatory processes in the joint. T cells are the major inflammatory cells in the rheumatoid inflammatory tissues (Abrahamsen et al. 1975). Sin

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https://doi.org/10.1007/978-3-476-04410-5finding of a highly restricted variable (V)α or Vβ usage by T cells from animals experimentally induced to respond to self antigens, such as myelin basic protein (MBP) (Acha-Orbea H., 1988) or type 2 collagen (David C.S., 1989, Chiocchia G., 1991), may not necessarily be true for spontaneously-trigg

Stress

https://doi.org/10.1007/978-3-476-04410-5 a functional loss of the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane, which is the result of the effects of anti-AChR antibodies and complement (Lindstrom ., 1988). Many caucasian MG patients possess HLA-B8, and those having a subtype of the DR3 haplotype polymorphic at the