Titlebook: Assessment of Cell Proliferation in Clinical Practice; Peter A. Hall (Professor of Histopathology),David Book 1992 Springer-Verlag London

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978-1-4471-3192-2Springer-Verlag London Limited 1992

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Flow Cytometry,Flow cytometry has developed over the past 30 years from initial attempts to count and size particles. The first cell sorter was described in 1965, and multiparameter machines measuring two fluorescence wavelengths were described around 1970. An excellent summary of the historical development of flow cytometers is given by Melamed et al. (1990a).

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Nucleolar Organiser Regions,Nucleolar organiser regions (NORs) are the genomic DNA segments encoding for ribosomal RNA. They can be visualised in chromosome preparations and in interphase nuclei because each NOR is associated with argyrophilic protein; the silver-stained structures thus demonstrated are called AgNORs.

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Radiology in Suspected Child Abuse,ome condensation, nuclear envelope breakdown and spindle formation. With the advent of suitable radioactive tracers, it soon became clear that events relevant to cell division, notably DNA replication, actually began many hours before mitosis (Howard and Pelc 1953). This led to the subdivision of in

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https://doi.org/10.1057/9781137413758der what we want to measure. The commonest question is “can we say that cells in this tissue are being produced faster than in that?” Such questions demand a viable technique giving reproducible and unequivocal results that have discriminatory power in statistical tests, and it should be appreciated

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The Treatment of Electronic Organizers,he socalled cell renewal systems, are in a constant state of division, maturation and loss, for example in skin and gut. The process of homeostasis keeps the balance between cell production and cell loss so that the cell proliferation rate is exactly balanced by cell loss. It is a fundamental part o