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Titlebook: Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy; Matthias J.N.Junk Book 2012 Springer-Verlag Berlin Heide

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期刊全称Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy
影响因子2023Matthias J.N.Junk
视频video
发行地址Nominated by Max-Planck-Institute for Polymer Research, Mainz, Germany.Innovative approach to assess the topic.Delivers remarkable new insights into materials.Includes supplementary material:
学科分类Springer Theses
图书封面Titlebook: Assessing the Functional Structure of Molecular Transporters by EPR Spectroscopy;  Matthias J.N.Junk Book 2012 Springer-Verlag Berlin Heide
影响因子In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure – a consequence of the protein’s adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material’s hosting properties and enable unforeseen complex catalytic functionalities.
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Nano-Inhomogeneities in Structure and Reactivity of Thermoresponsive Hydrogels,PR spectroscopy. Via addition of paramagnetic tracer molecules, so-called spin probes, the thermally induced collapse is monitored on the molecular scale and is found to proceed over a substantially broader temperature range than indicated by the sharp macroscopic volume transition.
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Conclusion,eir structural heterogeneities on the molecular and nanoscopic level they can host and transport small molecules. By employing EPR-active probe molecules and ions, the . structure of these materials was examined from the unique perspective of guest molecules that are incorporated in the systems and
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,Canned Food and Canned Death: ,is, the amphiphilicity in its original definition is studied, namely the chimeric affinity of molecules for water due to hydrophilic and hydrophobic groups. In particular, amphiphiles have a tendency to self-assemble into larger structures due to partly non-favorable interactions with a solvent.
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