Titlebook: Artificial Oxygen Carrier; Its Frontline Koichi Kobayashi (Chief Professor of Surgery),Eish Conference proceedings 2005 Springer-Verlag Tok

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New Strategy for the Preparation of NO-Treated Red Blood Cells as a Blood Substitute,ric oxide (NO) [Yonetani et al., (1998) J Biol Chem 273: 20323], have shown that the α-nitrosyl HbA is a cooperative, low-affinity oxygen carrier. We have developed a simple method to convert all the intra-human red blood cells (RBCs) to a 50% saturation of hemes with NO exclusively bound to the α-s

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Oxygen-Carrying Plasma Hemoprotein Including Synthetic Heme,-heme, is an entirely synthetic hemoprotein that can reversibly bind and release O. under physiological conditions. We have recently found that replacing the substituent groups of FepivP with more hydrophobic 1-methylcyclohexanoylamino groups, affording FecycP, substantially stabilizes the formed O.

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https://doi.org/10.1007/978-1-4939-7113-8p50 in humans is scant. In the case of cell-free hemoglobin, the mechanisms of O. transfer to tissue are completely different, such that unless p50 is significantly reduced, O. oversupply will result, engaging autoregulatory mechanisms that leads to vasoconstriction. A second generation of O. carrie

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Tianfa Xie,Jamar Hawkins,Yubing Sun In rabbit jejunum membranes, superfused under hypoxic conditions, the presence of the DECA allowed metabolites transport across the mucosa. Equivalent suspensions of red cells failed to allow transport. It is suggested that non-extravasating HBOC with high oxygen affinity can still deliver oxygen t