Titlebook: Arterial Chemoreception; From Molecules to Sy Colin A. Nurse,Constancio Gonzalez,Nanduri Prabhak Conference proceedings 2012 The Editor(s)

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Ion Channel Regulation by the LKB1-AMPK Signalling Pathway: The Key to Carotid Body Activation by Hon of AMP-activated protein kinase (AMPK) mediates carotid body excitation by hypoxia. Consistent with the effects of hypoxia, intracellular dialysis from a patch pipette of an active (thiophosphorylated) recombinant AMPK heterotrimer (α2β2γ1) or application of the AMPK activators AICAR and A769662:

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Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells,n response to hypoxia is unclear. In the present study we seek to determine iron and calcium redistribution patterns in response to hypoxia in the cat chemoreceptor cells. Four cats were used: two each exposed to normoxia (PaO. = 90 mmHg) and hypoxia (PaO. = 20 mmHg) for 40 min. Carotid bodies were

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Acute Hypoxia Does Not Influence Intracellular pH in Isolated Rat Carotid Body Type I Cells,uring this challenge. Multiple studies have attempted to address this issue but data are contradictory and methods poorly defined (Wilding et al. 1993; Pang and Eyzaguirre 1993). Wilding et al. used BCECF loaded, isolated Type I cells and demonstrated that ‘hypoxia’ did not cause a change in pH.. Ho

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The Retrotrapezoid Nucleus and Breathing,matergic neurons that are non-aminergic and express homeodomain transcription factor Phox2b throughout life. These neurons respond vigorously to increases in local pCO. via cell-autonomous and paracrine (glial) mechanisms and receive additional chemosensory information from the carotid bodies. RTN n

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The Interaction Between Low Glucose and Hypoxia in the ,, Rat Carotid Body, and dogs . showed that intra-arterial injection of sodium cyanide into the carotid sinus region immediately increased carotid sinus nerve (CSN) discharge frequency and elicited a subsequent significant increase in the systemic arterial glucose concentration, within 2–8 min of drug administration (A

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Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Press play a role in the counterregulatory response to hypoglycemia in animal models and may interact with the arterial baroreflex. We hypothesized that desensitization of the carotid bodies by hyperoxia in humans would blunt hypoglycemic counterregulation and baroreflex control of blood pressure during

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e-Development Toward the Knowledge Economyt in 12-days old pups. This response was similar between the dose of 4 and 8 mg/kg. These observations suggested that progesterone enhances in age- and dose-dependent manner the hypoxic ventilatory response in newborn rats.