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Titlebook: Aptamers Selected by Cell-SELEX for Theranostics; Weihong Tan,Xiaohong Fang Book 2015 Springer-Verlag Berlin Heidelberg 2015 Aptamer-based

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Fundamental Theories of Physicsl antibodies in molecular recognition for many applications in biomedicine and biotechnology such as biosensing, bioimaging, and drug. In particular, a recently developed method of live cell-based in vitro selection, termed cell-SELEX, has successfully isolated aptamers without prior knowledge of a
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https://doi.org/10.1007/978-3-658-11970-6lecular mechanisms underlying pathogenesis, as well as accurately diagnosing disease states and monitoring therapeutic modalities. Cell-SELEX is a foundational tool used to select probes able to recognize molecular signatures on the surface of diseased cells. This technology has been increasingly us
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https://doi.org/10.1007/978-3-658-11970-6t to cover the natural shortages of nucleic acids, including lack of binding functional diversity and low information densities, has never been stopped. Strategies proposed to improve the aptamer properties include post-selective modifications and introducing unnatural nucleic acids in SELEX process
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https://doi.org/10.1007/978-3-658-11970-6of aptamers would provide better and deeper understanding and facilitate the development of customized aptamer-based diagnostics and therapeutics with enhanced performance. In this chapter, key properties of cell-specific aptamers and their characterization are discussed.
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