Titlebook: Applied Toxicology: Approaches Through Basic Science; Proceedings of the 1 Jürg P. Seiler,Eugenio Vilanova Conference proceedings 1997 Spri

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Regulation and Mechanisms of Apoptosis in T Lymphocytesy morphological and biochemical changes in most cell compartments (Kerr et al., 1972; Wyllie et al., 1980). The microscopically observed nuclear alterations such as marginatiom and condensation of chromatin and nuclear fragmentation are accompanied by sequential degradation of the DNA, first into fr

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Options for the Regulation and Control of the Environmental Impact and Human Health Consequences of s to chemical regulation. In doing so, it reviews the current European Union approach to the regulation of hazardous chemicals, and considers the recent Green Paper (1993) proposals on the use of a civil liability system for environmental regulation. The conclusions that emerge from this discussion

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The Identification of Thresholds of Acceptability and Danger: The Chemical Presence Routethe exposure of new and existing chemicals to aquatic and terrestrial ecosystems. Current methods use local models for air, water and soil to estimate chemical concentrations close to the source and a generic multimedia ‘unit world’ approach to estimate regional PECs. These models assume generic env

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The Precautionary Principle and Science-based Limits in Regulatory Toxicology: The Human Experience,ised the legislation which gives effect to those concerns. The many legal instruments issued by the appropriate Directorates General have seen the introduction of new controls in some member states as well as the overall harmonization of controls amongst those member states which had national legisl

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History of Forebrain Commissurotomyenetic polymorphism of the corresponding genes, as well as to physiological-, environmental- and pathological factors. From a teleological point of view it is evident that genetically based interindividual variability is seen in the human lymphocyte antigen (HLA) system, the immune system and in the

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