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Titlebook: Applied Neurogenomics; Kewal K. Jain Book 2015 Springer Science+Business Media New York 2015 Clinical applications.Genomic technologies.Ne

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发表于 2025-3-21 18:01:04 | 显示全部楼层 |阅读模式
期刊全称Applied Neurogenomics
影响因子2023Kewal K. Jain
视频video
发行地址Includes relevant methods and coverage of technologies.Provides step-by-step detail essential for reproducible results.Addresses the rapid progress in next generation sequencing
学科分类Neuromethods
图书封面Titlebook: Applied Neurogenomics;  Kewal K. Jain Book 2015 Springer Science+Business Media New York 2015 Clinical applications.Genomic technologies.Ne
影响因子.This detailed volume reflects the considerable new developments that have taken place in the area of applied neurogenomics, particularly with the rapid progress in next generation sequencing. Beginning with an introduction to the technologies relevant to neurogenomics with an emphasis on next generation sequencing, the book also covers detailed methods relevant to the genomics of neurodegenerative diseases, particularly Alzheimer’s disease and Huntington’s disease, targeted sequencing of psychiatric disorders, as well as the role of genomics in the development of personalized neurology. Written in the popular .Neuromethods. series format, chapters provide the kind of practical description and implementation advice necessary to consistently produce successful results in the lab..Timely and convenient, .Applied Neurogenomics. serves as an invaluable reference for researchers working in this expanding, dynamic field..
Pindex Book 2015
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发表于 2025-3-21 23:40:10 | 显示全部楼层
,Gene Expression-Based Approaches to Understanding Huntington’s Disease and New Tools for the Interpopathologic mechanisms of Huntingtin toxicity include transcriptional dysregulation [reviewed in Luthi-Carter (Drug Dis Today Dis Mech 4:111–119, 2007)], and a strikingly characteristic set of HD-related changes in gene expression have been informative in assessing model systems and underlying patho
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,RNA Sequencing from Laser Capture Microdissected Brain Tissue to Study Normal Aging and Alzheimer’sinvestigated. RNA-Seq is a major advance for the field due to its largely unbiased and digital nature, its ability to empower RNA splice form construction at a genomic level, and its improved dynamic range when compared to a microarray technology. Investigating the healthy or diseased brain presents
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Determination durch andere Substanzenopathologic mechanisms of Huntingtin toxicity include transcriptional dysregulation [reviewed in Luthi-Carter (Drug Dis Today Dis Mech 4:111–119, 2007)], and a strikingly characteristic set of HD-related changes in gene expression have been informative in assessing model systems and underlying patho
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Determination durch andere Substanzen still no effective cure. A combination of novel genomic approaches and techniques such as chromatin immunoprecipitation sequencing (ChIP-seq) and RNA-seq that enable high-quality data could provide better understanding of transcriptional and epigenetic signatures useful for both biomarker developme
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