Titlebook: Applications of Pharmacokinetic Principles in Drug Development; Rajesh Krishna Textbook 2004 Kluwer Academic/Plenum Publishers, New York 2

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https://doi.org/10.1007/978-3-662-26791-2ormation in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The purpose of population modeling is thus to describe and capture our experience with the behavior of a drug in a certai

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Nijhoff International Philosophy Seriesction to important soft tissues, and it serves as mechanical pivot and provides the mechanical advantage to muscles that makes possible the versatility of movement characteristic of these organisms. In addition to its mechanical functions, bone tissue, which constitutes the bulk of the skeletal mass

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Sebastian Schief Dr., Dipl. Soz.ts dosage between one that is too low, and likely to be ineffective on the one hand, or too high, and likely to be toxic, on the other. We must carefully plan and individualize the dosage for each patient, to achieve some desired target goal such as a serum concentration, or its profile over time. W

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978-1-4613-4842-9Kluwer Academic/Plenum Publishers, New York 2004

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H. J. Schmid,D. Rühland,U. Augenstein both drugs and putative metabolites in biological matrices such as blood, plasma, serum and urine. Additionally, significantly greater attention is being focused on the metabolic liabilities of these compounds at earlier stages in drug development than ever before. In a continuing effort to keep up