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Titlebook: Application and Integration of Omics-powered Diagnostics in Clinical and Public Health Microbiology; Jacob Moran-Gilad,Yael Yagel Book 202

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,Advanced Applications of MALDI-TOF MS – Typing and Beyond,evel. In this chapter, we will discuss the challenges and opportunities of bacterial typing using MALDI-TOF MS, beyond species identification, and review the current experience with different typing approaches with regards to several clinically significant bacteria.
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Optimality Aspects of Carleman Estimateswill review the main current and foreseen clinical applications where WGS has or could have an added value regarding the presence of virulence factors. In addition, we will discuss the main technical approaches and limitations of WGS as well as the validation and interpretation of the results.
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A Short Review of Distribution Theoryacterial core and accessory genome. In this chapter, we will review the general concepts of typing, as well as the various available typing techniques, and discuss both the advantages and the challenges of using WGS for typing purposes.
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Epidemiological Typing Using WGS,acterial core and accessory genome. In this chapter, we will review the general concepts of typing, as well as the various available typing techniques, and discuss both the advantages and the challenges of using WGS for typing purposes.
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Integrating Metagenomics in the Routine Lab,common hurdles encountered when attempting to utilise CMg to clinical samples (such as sample preparation and wet lab issues and bioinformatic challenges) and discuss ways to overcome them. We will also review the current experience with using CMg in clinical samples from different anatomical sites.
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