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Titlebook: Anxiolytic β-Carbolines; From Molecular Biolo David N. Stephens Book 1993 Springer-Verlag Berlin Heidelberg 1993 Beta Carboline.GABA.anxiet

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期刊全称Anxiolytic β-Carbolines
期刊简称From Molecular Biolo
影响因子2023David N. Stephens
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学科分类Psychopharmacology Series
图书封面Titlebook: Anxiolytic β-Carbolines; From Molecular Biolo David N. Stephens Book 1993 Springer-Verlag Berlin Heidelberg 1993 Beta Carboline.GABA.anxiet
影响因子Since the discovery some 15 years ago of benzodiazepinemodulatory sitesassociated with GABA A receptors, greateffort has gone into understandingtheir molecularpharmacology and into developing new anxiolytic drugs thatinteract selectively with them. Prominent in this researchhas beenthe discovery that ~-carbolines, a differentchemical class frombenzodiazepines, also act at thesereceptors but that their effects are sometimes quitedifferent from those of the benzodiazepines.Thisbookdocuments the latest discoveries in the molecularbiology of the GABA A receptor and reveals howan integration of the results of research inmolecularbiology, synthetic chemistry, biochemical and behavioralpharmacology, and clinical pharmacology has paved the wayforthe development of ~-carbolines from substances inducinganxiety andconvulsions to a novel therapy for anxietystates, achieving a behavioral selectivity through selectiveactions at subtypes of receptors.
Pindex Book 1993
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Elektrische und magnetische Felderlasses called α, β, γ, δ and ρ, have been cloned. Each class consists of several subunit isotypes (for example α.-α.), which may differ only in few amino acids but which differ markedly in their expression patterns in the CNS, both in adulthood and during development.
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https://doi.org/10.1007/978-3-662-36759-9. 1992). Specifically, tolerance, withdrawal, self-injection, and drug discrimination were evaluated with abecarnil using methods for which data have been previously reported for benzodiazepines and related novel compounds
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Behavioral Pharmacology of Abecarnil in Baboons: Reduced Dependence and Abuse Potential,. 1992). Specifically, tolerance, withdrawal, self-injection, and drug discrimination were evaluated with abecarnil using methods for which data have been previously reported for benzodiazepines and related novel compounds
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Book 1993molecularpharmacology and into developing new anxiolytic drugs thatinteract selectively with them. Prominent in this researchhas beenthe discovery that ~-carbolines, a differentchemical class frombenzodiazepines, also act at thesereceptors but that their effects are sometimes quitedifferent from tho
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Abecarnil is a Full Agonist at Some, and a Partial Agonist at Other Recombinant GABAA Receptor Subtlasses called α, β, γ, δ and ρ, have been cloned. Each class consists of several subunit isotypes (for example α.-α.), which may differ only in few amino acids but which differ markedly in their expression patterns in the CNS, both in adulthood and during development.
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