Titlebook: Antimicrobial Drug Resistance; Mechanisms of Drug R Douglas L. Mayers Book 2009 Humana Press 2009 Drug.HIV.Handbook.Hepatitis.Malaria.Mayer

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en by individual microbial agents including bacteria, fungi, protozoa and viruses. Volume 2 addresses clinical, epidemiologic and public health aspects of drug resistance along with an overview of the conduct and interpretation of speci? c drug resistance assays. Together, these two volumes offer a comprehens978-1-62703-866-9978-1-59745-180-2

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Evolutionary Biology of Drug ResistanceThe acquisition of any type of resistance produces a change. In biology, any change is not only an opportunity, but is also a risk for evolution. Bacterial organisms are highly integrated functional structures, exquisitely tuned by evolutionary forces to fi t with their environments. Beyond the thre

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Antimicrobial Resistance Versus the Discovery and Development of New Antimicrobialsat in large pharmaceutical companies. Finally, we will speculate on the future of antibacterial discovery and development given the emerging trends in science, in the marketplace, within the regulatory environment, and in the context of the pharmaceutical business.

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Genetic Mechanisms of Transfer of Drug Resistanceknown to be composed of the replication and transfer functions of the plasmids, and the genes in these studies are now known to be on mobile elements (simple and composite transposons and integrons). The 1960s and 1970s saw a rapid increase in the number of antibiotics (particularly aminoglycosides

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Transport Mechanisms of Resistance to Drugs and Toxic Metalsugh some of these transporters extrude specifi c drugs and metals, others can extrude a wide range of structurally dissimilar drugs. Currently, much research is directed toward understanding the molecular mechanisms of these transport proteins. Potential clinical applications include the design of i

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Penicillin-Binding Proteins and β-Lactam Resistanceses or endopeptidases rather than transpeptidases. In the intervening three decades, intense research has been carried out on PBPs, particularly on their role in the resistance to -lactams of some important pathogens such as ., . and ..

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https://doi.org/10.1007/978-981-13-3444-3The acquisition of any type of resistance produces a change. In biology, any change is not only an opportunity, but is also a risk for evolution. Bacterial organisms are highly integrated functional structures, exquisitely tuned by evolutionary forces to fi t with their environments. Beyond the thre

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