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Titlebook: Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment; Roberto L. Ceriani Book 1994 The Editor(s) (if applic

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发表于 2025-3-21 19:56:48 | 显示全部楼层 |阅读模式
期刊全称Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment
影响因子2023Roberto L. Ceriani
视频video
学科分类Advances in Experimental Medicine and Biology
图书封面Titlebook: Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment;  Roberto L. Ceriani Book 1994 The Editor(s) (if applic
影响因子Today, advances in the area of immunology and breast cancer are made at an increasing rate, yielding an amount of information that can become unwieldy. The opportunity for scientists in this area of research to gather together to exchange results and working hypotheses represents, in my belief, a very attractive proposition. With this in mind, these workshops have been convened with two year intervals for the last ten years. In each of them, selected topics have been highlighted. The present workshop underscores the large advancements made in the molecular biology of both breast cancer associated antigens and their corresponding antibodies. Understanding the genetic information for the expression of these antigens has been recently advanced leading to preparation of molecularly engineered reagents for use in vaccination, serum assays, and immunizations for novel antibody production. In the anti-breast cancer antibody field the availability of molecular engineering approaches to humanize murine antibodies has induced intense interest in the creation of less immunogenic antibody forms that are now available for clinical testing. Clinical studies using anti-breast murine antibody cont
Pindex Book 1994
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发表于 2025-3-21 20:49:53 | 显示全部楼层
Peptide Epitopes in Breast Cancer Mucins, is the predominant mucin expressed in breast cancer.. In addition, other genes coding for mucins have been identified which are expressed in a variety of tissues, and are also found in breast tissue and to a lesser extent in breast cancer (particularly MUC2 and MUC3). It was of interest that these
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Humanization of an Anti-Mucin Antibody for Breast and Ovarian Cancer Therapy,oclonal antibody, CTM01 (mCTM0l), which recognizes an epitope on breast epithelial mucin, has potential for the treatment of breast and ovarian cancers. We examine in this paper the comparative properties of mCTM01 against a number of other anti-mucin antibodies. We then describe the humanization an
发表于 2025-3-23 02:29:40 | 显示全部楼层
Towards an Immunotherapy for p185HER2 Overexpressing Tumors,). . was found to be amplified from 2 to 20-fold in up to ~ 30% of primary human breast cancers.. Furthermore, . amplification was shown to be a strong prognosticator of decreased overall survival and overall time to relapse.. amplification and/or overexpression has subsequently been correlated with
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Branching N-Linked Oligosaccharides in Breast Cancer,nching, a regulatory step in expression of polylactosamine and extended-chain Lewis antigens. Loss of the branched oligosaccharides in murine tumor cells either due to somatic mutation, or treatment of the cells with the oligosaccharide processing inhibitor swainsonine, blocks tumor cells invasion i
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