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Titlebook: Antidepressants; Brian E. Leonard Book 2001 Springer Basel AG 2001 clinical research.depression.immune system.pharmacology.psychopharmacol

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Long-term course, comorbidity and long-term outcome in depressive disordersuded in clinical trials and patients in clinical practice [.]. In clinical practice psychiatric comorbidity is common, while those patients often are excluded from clinical trials. In the same way, somatic comorbidity is common in clinical practice [.], while those patients often are excluded in clinical trials.
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The hypothalamic-pituitary-adrenal axis and antidepressant actionHPA. The SAM by triggering catecholamine release provides the acute stress response, whilst the HPA governs longer term stress defence mechanisms. Together these systems regulate energy utilisation and metabolic activity throughout the body.
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Neuroendocrine markers of depression and antidepressant drug actionthe density of specific neurotransmitter binding sites in discrete brain regions [.]. Furthermore the use of ligand binding together with pharmacological manipulation of endogenous neurotransmitter release can be used to measure neurotransmitter release . [.].
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https://doi.org/10.1007/978-3-663-07852-4HPA. The SAM by triggering catecholamine release provides the acute stress response, whilst the HPA governs longer term stress defence mechanisms. Together these systems regulate energy utilisation and metabolic activity throughout the body.
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https://doi.org/10.1007/978-3-663-07852-4the density of specific neurotransmitter binding sites in discrete brain regions [.]. Furthermore the use of ligand binding together with pharmacological manipulation of endogenous neurotransmitter release can be used to measure neurotransmitter release . [.].
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