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Titlebook: Anticlastogens in Mammalian and Human Cells; Erich Gebhart,Ruben M. Arutyunyan Book 1991 Springer-Verlag Berlin Heidelberg 1991 Antimutage

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https://doi.org/10.1007/3-540-33200-6he practical meaning of induced mutations is substantiated by the manifold evidence of their detrimental consequences in man. Mutations in germ cells can cause a large variety of genetic diseases which have been (more or less) well defined by medical genetics (McKusick 1988). Far more than 4000 mono
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https://doi.org/10.1007/3-540-33200-6ng from a genotoxic influence in the studied test system. In this sense, an anticlastoge-nic effect can be estimated by a statistical comparison of the quantitative outcome of experiments performed with the clastogen alone and those including the addition of an anticlastogen. As will be shown below,
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The First Solution and the Last Statement,or anticlastogen research itself have to be considered, including the possibilities and limitations of future test strategies; and, second, the consequences of the findings of anticlastogenesis research for human risk populations must be discussed. This must also include considerations on the compat
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Book 1991and synthetic antimutagens, which, because of their specific action on clastogenic damage are called anticlastogens. Based on an introductory chapter on nature and mode of formation of chromosome aberrations induced by chemical and also physical mutagens, the action of anticlastogens is discussed in
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The First Solution and the Last Statement,uences of the findings of anticlastogenesis research for human risk populations must be discussed. This must also include considerations on the compatibility of anticlastogens and the knowledge gained from their practical application in other (e.g., therapy) fields.
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