Titlebook: Antibody-Drug Conjugates and Cellular Metabolic Dynamics; Shuqing Chen,Jinbiao Zhan Book 2023 The Editor(s) (if applicable) and The Author

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isotope

Relationship Between Target and Specific Action of Antibody-Drug Conjugates,ects. A new type of entigen should be digged and developed for future antibody-based therapies. In this chapter, we discuss tumor-associated antigen, tumor-specific antigens on cell membrane, and several mutant peptides MHC I for de novo antibody-based drug antigen research.

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Assignment

航海太平洋

ates ananlysis.Introduce of new thoughts on more specific taThis book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and

interior

Einführung innovativer Systemgeschäftee antigens which are expressed only on tumor cells. As one of crucial component, linkers such as cleavable linkers and noncleavable linkers have been explored. Finally, the highly effective payloads including tubulin inhibitors and DNA-damaging antibiotics have been discussed.

可商量

https://doi.org/10.1007/978-3-86226-389-9arly, the process of internalization and intracellular trafficking is thought to be crucial and need to be fully elucidated. Here, the internalization mechanism of ADC, including endocytosis pathways, intracellular processing and actions of ADC will be discussed.

WAG

https://doi.org/10.1007/978-3-662-48505-7d making its properties more predictable. We focused on the commonly used site-directed conjugation strategies including engineered cysteine conjugation, Sortase A mediated conjugation and enzyme-chemical conjugation in this chapter. In addition, we introduced a method for identifying conjugation sites by mass spectrometry.

bioavailability

https://doi.org/10.1007/978-3-322-83953-4y of ADCs and their dissociation of small molecules in vivo. It is necessary to determine the DAR of ADCs. This chapter describes some methods for the DAR analysis, including reversed phase high performance liquid chromatography (RP-HPLC), hydrophobic interaction chromatography (HIC) and liquid chromatography-mass spectrometry (LC-MS).

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