Titlebook: Antibodies for Treating Cancer; Basics, Development, Melvyn Little Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusi

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https://doi.org/10.1007/978-3-322-92045-4s of other antibodies to make bispecific or even multispecific recombinant antibodies. For example, dual binding antibodies can be used to recruit immune cells for inducing the lysis of tumor cells. To avoid the rapid excretion of these relatively small fragments from the circulation, they can be fu

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Generation, Structure, and Function of Antibodies, Further diversity is created after an antigen binds to a B lymphocyte in the germinal centers. This stimulates B-cell proliferation and initiates a system for introducing a high number of mutations (somatic hypermutation) into the DNA region coding for the antigen-binding CDRs (complementarity-dete

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Of Mice and Men: Production of Therapeutic Antibodies,ntibodies. To screen these enormous libraries, the clonal selection system of the immune system was also imitated by coupling the antibody gene with its antibody product expressed on the surface of a microorganism, usually a bacteriophage. Those microorganisms were selected that bound with the highe

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Mediation of Tumor Cell Death by Naked Antibodies,id tumors. They have opened a window for treating cancers such as malignant melanomas that were previously resistant to therapy. Tumors that are particularly amenable to treatment with IC inhibitors are characterized by a high mutation rate and a significant number of tumor-infiltrating lymphocytes

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Novel Modular Antibodies,s of other antibodies to make bispecific or even multispecific recombinant antibodies. For example, dual binding antibodies can be used to recruit immune cells for inducing the lysis of tumor cells. To avoid the rapid excretion of these relatively small fragments from the circulation, they can be fu

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Recruiting Killer Cells for Cancer Therapy,cells), namely, Kymriah and Yescarta targeting CD19, achieved a high number of complete responses in the treatment of refractory or relapsed B-ALL and diffuse large B-cell lymphoma (DLBCL). An increasing number of novel strategies are being developed to optimize CAR-T cell efficacy and overcome the

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Cancer Incidence: Market for Therapeutic Antibodies,cted to overtake Humira as the top-selling biological drug. The median price of mAbs for 1 year of treatment in the United States in the area of oncology/hematology in 2019 was about $143,000. To facilitate decisions regarding reimbursement, some countries have established cost-effectiveness thresho