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Titlebook: Antibodies; Volume 2: Novel Tech G. Subramanian Book 2004 Springer Science+Business Media New York 2004 HIV.cancer.cancer therapy.cells.dev

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期刊全称Antibodies
期刊简称Volume 2: Novel Tech
影响因子2023G. Subramanian
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图书封面Titlebook: Antibodies; Volume 2: Novel Tech G. Subramanian Book 2004 Springer Science+Business Media New York 2004 HIV.cancer.cancer therapy.cells.dev
影响因子It is now over one hundred years since von Behring and Kitsato first concluded experiments that led to the use of passive immunisation, employing antibodies raised in animals against tetanus and diphtheria toxins. The advancement of technology both in manufacturing purity product in a cost effective way and the clinical research has proved that antibodies are one ofthe most successful products in biotechnology. Monoclonal antibodies account for between one-third and one-halfof all pharmaceutical products in development and human clinical trials. Both the nature of monoclonal antibody therapies and the relatively large size of the monoclonal antibody dictate the production requirements, for many ofthese therapeutics the monoclonal antibody product will be 100 kilogrammes or more per year. It is widely acknowledged that there is currently a worldwide shortage of biomanufacturing capacity, and the active pharmaceutical ingredient material requirements for these products are expected to increase. Thus the industry is looking for new sources and extensive studies are being carried out not only for alternative technology to meet the needs but also to reveal the new therapeutic applicatio
Pindex Book 2004
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Intrabodies: Development and Application in Functional Genomics and Therapy,is to interfere with their expression (.). Approaches such as gene knockout, antisense oligonucleotide or RNA interference (RNAi) are currently used to study gene and protein function and to validate candidate drug targets by analysing the effects of their deletion. One limitation of all these techn
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Expression of Recombinant Antibodies by Tumour Cells: On Road to Anti-Tumour Therapy, represent exciting tools for the targeted delivery of drugs, enzymes, and toxins at the site of the tumours. In addition, antibody-based radio-immunotherapy (RIT) should make it possible to circumvent the limitation of the treatment of solid tumours with antibodies due to the weak penetration of in
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Regine Witkowski,Falko H. Herrmann genetic engineering has allowed the conversion of existing mouse monoclonal antibodies into chimeric mouse-human antibodies, and humanised molecules where only the complementarity-determining regions (CDR) are of murine origin (.). To date, 13 therapeutic antibodies have obtained regulatory approva
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