Titlebook: Anthrax; Theresa M. Koehler Book 2002 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE

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Anthrax Vaccines, Live attenuated vaccines against anthrax in domesticated animals were among the very first vaccines developed. This was followed by the development of nonliving component vaccines leading to the eventual licensure of protein-based vaccines for human use in the 1970s. This chapter will review the re

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Structure and Function of Anthrax Toxin,presence of a host cell-surface receptor, PA can mediate the delivery of EF and LF from the extracellular milieu into the host cell cytosol to effect toxicity.In this delivery, PA undergoes multiple structural changes — from a monomer to a heptameric prepore to a membrane-spanning heptameric pore. T

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Genetics and Virulence Gene Regulation,n the structural genes for the anthrax toxin proteins, ., and ., the biosynthetic genes for capsule synthesis, ., and ., and a gene associated with depolymerization of capsule, .. The three toxin genes are located at distinct loci on pXO1, while the . and . genes are arranged in an apparent operon o

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,Elements of Continuum Mechanics for Fluid Flow and General Stress–Strain System,hing but the first law of thermodynamics applied to a control volume system. While for solids and liquids, the properties vary continuously in their macroscopic states, it is not so apparent for gases, which is characterized by mobility at the molecular level. One describes the flow of gases from th