Titlebook: Anthracycline Chemistry and Biology I; Biological Occurence Karsten Krohn Book 2008 Springer-Verlag Berlin Heidelberg 2008 Base.Chemical sy

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Synthesis of the Sugar Moietiesresented and their capability for scale-up andprocess development are commented upon. Rational sugar structural modifications, which are eitheruseful for synthetic purposes or offer advantages in experimental therapy of cancer, are discussedfrom the chemical point of view.

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https://doi.org/10.1007/978-3-663-13473-2of the biosynthetic pathwaysof anthracyclines have been made. Insights into the mechanistic features of the enzymes involvedare expected to have implications for the production of novel compounds with improved therapeuticprofiles by combinatorial biosynthesis.

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https://doi.org/10.1007/978-3-476-99781-4halic anhydrideswith the carbon–carbon double bond and the reaction mechanism, especially addressing the regiochemistryof the reaction, and (iii) application of the reaction to the efficient asymmetric syntheses of anthracyclinesand fredericamycin A.

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https://doi.org/10.1007/978-3-540-75815-0Base; Chemical synthesis; Cycloaddition; DNA; Enantiomer; biology; enzymes