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Titlebook: Antenatal Diagnosis of Fetal Abnormalities; James O. Drife (Professor of Obstetrics and Gynaec Book 1991 Springer-Verlag London Limited 19

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Chorion Villus Sampling: The MRC European Trialond trimester. The clinical rationale was the possibility of earlier and easier termination of abnormal pregnancies after CVS, the benefits of which would have to be set against potentially higher fetal loss rates.
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Diagnosis of Genetic Defects in Eggs and Embryos to terminate the pregnancy by abortion. Some couples may suffer the considerable trauma of repeated pregnancy terminations. Hence, attention has been focused on diagnosis in embryos before implantation.
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Advances in Diagnosis of Biochemical Disorderss. The important work on normal and abnormal haemoglobins by Pauling, Ingram and others led the way to the search for the responsible (enzyme) protein defects in other genetic diseases and during the past three decades nearly 400 genetic protein defects have been identified. This has offered new perspectives in health care and in basic research.
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