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Titlebook: Annual Update in Intensive Care and Emergency Medicine 2016; Jean-Louis Vincent Book 2016 Springer International Publishing Switzerland 20

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Immunomodulation: The Future for Sepsis?results in the intense release of pro- and anti-inflammatory cytokines. Essential and beneficial to the host when controlled and adapted, this “cytokine storm” can become harmful when unbalanced. Whereas patients whose immune status remains close to homeostasis are more likely to survive, uncontroll
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Norepinephrine in Septic Shock: Five Reasons to Initiate it Earlyent are initiated, including administration of fluid and of vasopressors to target a mean arterial pressure (MAP) > 65mmHg [1]. Currently, the early use of vasopressors is one of the emerging concepts in the hemodynamic management of septic shock that may change our practice. In this chapter, we wil
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Detrimental Cross-Talk Between Sepsis and Acute Kidney Injury: New Pathogenic Mechanisms, Early Biom immune system and lead to the subsequent development of sepsis. In this chapter, we review the recent findings on the detrimental cross-talk between sepsis and AKI and the identification of new, early biomarkers and targeted therapies aimed at improving the outcome of these critically ill patients.
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(Multiple) Organ Support Therapy Beyond AKImbrane oxygenation [ECMO] or molecular adsorbent recycling system [MARS] on CRRT). Current developments and the future of MOST foresee the application of dedicated and integrated multipurpose advanced platforms for the support of patients with MOF. This review will detail extracorporeal blood purifi
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