Titlebook: Annual Reports in Combinatorial Chemistry and Molecular Diversity; W. H. Moos,M. R. Pavia Book 1999 Springer Science+Business Media Dordre

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1384-2811 he preparation of drug candidates, the automated,permutational, and combinatorial use of chemical building blocks nowallows the generation and screening of unprecedented numbers ofcompounds. Drug discovery - better, faster, cheaper? Indeedmore compounds have been made and screened in the 1990s than

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Raymond Opdenakker,Carin Cuypersiews some of the most important computational work in the field of diversity profiling and combinatorial library design, with particular emphasis on methodology and applications. It is divided into four sections that address issues related to molecular representation, dimensionality reduction, compound selection, and visualization.

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Advances in diversity profiling and combinatorial series design,iews some of the most important computational work in the field of diversity profiling and combinatorial library design, with particular emphasis on methodology and applications. It is divided into four sections that address issues related to molecular representation, dimensionality reduction, compound selection, and visualization.

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Book 1999tion of drug candidates, the automated,permutational, and combinatorial use of chemical building blocks nowallows the generation and screening of unprecedented numbers ofcompounds. Drug discovery - better, faster, cheaper? Indeedmore compounds have been made and screened in the 1990s than in thelast

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Solution-phase combinatorial chemistry,s in the drug discovery process. Solution-phase work is free from some of the constraints of solid-phase approaches but has disadvantages with respect to purification. This article will also illustrate some of the advances made in recent years in solution phase array chemistry including using suppor

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Purification of combinatorial libraries, has shifted toward smaller, more focused libraries for lead optimization. These focused libraries generally consist of individual discrete compounds. Biological assay requirements often require compounds of high purity, thus development of automated high throughput purification methods has received

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Accessing carbohydrate-based combinatorial libraries through solid phase and solution phase approac combinatorial libraries [1–3]. With genomics initiatives beginning to dramatically increase the number of interesting biomolecular targets, a great need has arisen for expanding the universe of molecular structures available for screening. Although carbohydrates play fundamental roles in many biolo