Titlebook: Animal and Plant Stem Cells; Concepts, Propagatio Mirjana Pavlović,Ksenija Radotić Book 2017 Springer International Publishing AG 2017 Bioe

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Essential Characteristics of Stem Cells: Self-renewal, and Plasticityo extraordinary, particular, and unique. Their characteristic features of self-renewal and plasticity make them necessary for everyday life of the body which is in constant renewal and recovery and must be maintained in perfect homeostasis in order to stay healthy and alive. The other two features,

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Stemness and Stem Cell Markersfferentiating into divergent functional cell lines. Different stem cells express different stem cell markers which are hallmarks of these cells together with adequate functionality. Sometimes the cells possess/express the markers (phenotype) but the function is lacking and therefore they cannot be c

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Expansion of Stem Cells: Propagation of Animal Stem Cells Ex Vivo (In Culture)for example, cord blood stem cells should not be stored at all, since their total yield was low. However, with the time, the methods for expansion have been developed and strongly supported the use of stem cells from different sources in clinical arena. Several approaches to expansion mainly through

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Induced Pluripotent Stem Cells (iPSCs) and Nuclear Reprogrammingeparative purposes. However, John Gurdon and Shinya Yamanaka, have discovered that nucleus of somatic adult cells can be reprogrammed to lead the cells into their pluripotency [.,.,.]. The methods of reprogramming, with focus on the use of nanoparticles, the features of i [.,.,.] PCs and their signi

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Metabolic Reprogramming in Cancer and Metabolic Theory of CSCs, based upon metabolic reprogramming which is today regarded as the essence of dramatic mechanisms in cancer stem cells. The genetic mechanisms were so much in trend that the work of Warburg, Pasteur, Crabtree, and Racker which was almost forgotten for several decades, emerges now again as inevitab

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Concept of Targeted Cancer Stem Cell Therapy and New Versionsng of molecular feature associated with CSC phenotype helped with the design of effective treatments. This concept envisions CSC as a unique target that should be destroyed with either physical, pharmacological, immunological, or even combined modalities, which do not affect normal cells. This chapt

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HLA Typization Choice of Donors: Match or Match Me Not. The role of MSH and HLA systems in diversification of these mechanisms is described and clarified. The significance of good match for successful engraftment is also emphasized. Some aspects of the matter are illustrated.

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