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Titlebook: Animal Models of Speech and Language Disorders; Santosh A. Helekar Book 2013 Springer Science+Business Media New York 2013

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Innovation und Entrepreneurshipht primarily reflect a deficit in ongoing neural signaling, rather than developmental miswiring. We explore genes co-regulated with . during singing and propose that Wnt trafficking and p63 signaling pathways may be crucial to speech and language.
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Innovation und Entrepreneurship resonance imaging experiments that reveal changes in neural activations produced by song stimuli in syllable repeater birds. Finally, we present findings and review data to propose that synaptic plasticity and neuromodulatory mechanisms might play a role in the development of repetitive or oscillatory vocal output.
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Genetic Pathways Implicated in Speech and Languageomplex, involving multiple risk factors. This chapter begins by discussing genetic loci associated with common multifactorial language-related impairments and goes on to detail the only gene (known as .) to be directly implicated in a rare monogenic speech and language disorder. Although . was initi
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Time Scales of Vocal Learning in Songbirdsciated with it, can be studied in songbirds under tight experimental control: One can control the when and what of vocal learning, record an entire vocal development, and measure neuronal activity in auditory and vocal brain centers while developmental learning takes place. Here we review recent fin
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Prospective: How the Zebra Finch Genome Strengthens Brain-Behavior Connections in Songbird Models ofed processes fundamental to vocal communication. Recently, the first songbird genome has been sequenced and assembled. The genome represents great opportunity to advance discovery of neural mechanisms of song. Notably, it enables simultaneous measurements of thousands of genes, prediction and testin
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Stuttered Birdsongbra finches can therefore be used to model speech motor control disorders. In this chapter, we describe our efforts at developing a variant form of zebra finch song containing syllable repetitions that resemble part-word repetitions of developmental stuttering. We further discuss functional magnetic
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