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Titlebook: Animal Models of Neurological Disease, II; Metabolic Encephalop Alan A. Boulton,Glen B. Baker,Roger F. Butterworth Book 1992 Springer Scien

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期刊全称Animal Models of Neurological Disease, II
期刊简称Metabolic Encephalop
影响因子2023Alan A. Boulton,Glen B. Baker,Roger F. Butterworth
视频video
学科分类Neuromethods
图书封面Titlebook: Animal Models of Neurological Disease, II; Metabolic Encephalop Alan A. Boulton,Glen B. Baker,Roger F. Butterworth Book 1992 Springer Scien
影响因子to the Animal Models Volumes This and several other volumes in the Neuromethods series will describe a number of animal models of neuropsychiatric disorders. Because of increasing public concern over the ethical treatment of animals in research, we felt it incumbent upon us to include this general preface to these volumes in order to indicate why we think further - search using animals is necessary and why animal models of psychiatric disorders, in particular, are so important. We recognize that animals should only be used when suitable alternatives are not available. We think it self-e- dent, however, that humans can only be experimented upon in severely proscribed circumstances and alternative pro- dures using cell or tissue culture are inadequate in any models requiring assessments of behavioral change or of complex in vivo processes. However, when the distress, discomfort, or pain to the animals outweighs the anticipated gains for human welfare, then the research is not ethical and should not be carried out. It is imperative that each individual researcher examine his/her own research from a critical moral standpoint - fore engaging in it, taking into consideration the animals’
Pindex Book 1992
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Animal Models of Brain Hypoxia, brain function has implications for understanding other metabolic encephalopathies as well as aging and age-related disorders, such as Alzheimer’s disease. Utilizing a variety of models of hypoxia is necessary to determine the effects of hypoxia on brain function and to test hypotheses about the un
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Animal Models of the Wernicke-Korsakoff Syndrome,nicke-Korsakoff syndrome. Disturbances of thiamine metabolism may also play a role in other human diseases, such as infantile subacute necrotizing encephalomyelopathy (Leigh Disease), as well as in some forms of inherited ataxias. One of the characteristics of a number of these thiamine-deficiency d
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Chemically Induced Models of Seizures,tive review of all chemical models, but rather a “how to” description of some of the more popular models that have yielded important data concerning mechanisms of seizure propagation. This chapter will examine seizure models that are directly related to chemical or drug administration, and not, for
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,Animal Models for Reye’s Syndrome, entity, but one that at that time was associated with an 80% mortality rate (.). Although the apparent incidence and outcome of the disease have improved, it continues to be one of the major causes of noninflammatory neurologic death after a viral illness in children (.; .).
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Animal Models of Niacin-Nicotinamide Deficiency, function of niacin was discovered. The recognition of pellagra as an endemic disease in the US dates from Searcy’s report in 1907 (.) describing 88 cases of dementia in the Mount Vernon, Alabama Insane Asylum. Extensive knowledge about the course of pellagra has since been obtained and this disease
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Pyridoxine Deficiency,al, and pyridoxamine, with similar physiological actions. They are referred to as vitamin B. vitamers. Pyridoxine is used synonymously with vitamin B.. Pyridoxal phosphate (PLP) is the major coenzymatic form of pyridoxine. There are over 100 known pyridoxal 5′-phosphate-dependent reactions, most of
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