Titlebook: Animal Models of Epilepsy; Methods and Innovati Scott C. Baraban Book 2009 The Editor(s) (if applicable) and The Author(s), under exclusive

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0893-2336 nd Innovations. is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder..978-1-4939-6114-6978-1-60327-263-6Series ISSN 0893-2336 Series E-ISSN 1940-6045

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https://doi.org/10.1007/978-94-009-5524-0nd often very resistant to standard medical therapies. In addition, patients with TSC also frequently suffer from autism as well as mental retardation and various psychiatric disorders. The causative . and . genes were identified in the 1990s. Despite tremendous growth in our knowledge of the . gene

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https://doi.org/10.1007/978-94-009-5524-0studies are useful in observing the physiological events that may occur during epileptogenesis, the great complexity of changes that ensue between first seizure and epilepsy makes it difficult to ascribe cause-and-effect to any single protein. In contrast, spontaneous mutations or mutations using ge

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W. G. Beeftink,J. Rozema,A. H. L. Huiskese the neuronal M-type potassium channel (M channel). While numerous studies have provided evidence for the inhibitory role of normally functioning M channels in key brain structures related to seizures and epileptogenesis, the BFNC sequelae from mutation to seizure and ultimately to remission is lik