Titlebook: Angiotensin Vol. I; Thomas Unger,Bernward A. Schölkens Book 2004 Springer-Verlag Berlin Heidelberg 2004 Aldosterone.Angiotensin.Angiotensi

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Renin-Angiotensin System: Plasma Versus Tissuess via circulating blood, has been challenged in the past two decades by studies demonstrating high tissue levels of angiotensin II, as well as release of angiotensin I from tissue sites. The high tissue levels of angiotensin II could not be explained on the basis of diffusion and/or receptor-mediate

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Knockout Models of the Renin-Angiotensin System different classes of G protein-coupled receptors, termed angiotensin II AT. receptors and AT. receptors. Transgenic mouse models have greatly advanced our understanding of the specific functions of the individual parts of the renin angiotensin aldosterone system (RAAS). Recently, all components of

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Transgenics of the RAS genes in rodents. It allows overexpression and—by the use of antisense constructs—also attenuation of gene expression in rats and mice. Transgenic technology has been extensively used to study the functions of the renin-angiotensin system (RAS). Most transgenic rat or mouse models overexpressing re

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Gene Therapy and the Renin-Angiotensin Systemstem offers targets that are know to be effective based on pharmaceutical drugs that have targeted angiotensin-converting enzyme (ACE) angiotensin type I receptors (AT.R). Other targets include renin and angiotensinogen. It is clear that lowering overactive amounts of angiotensin II has positive eff

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General Physiology and Pathophysiology of the Renin-Angiotensin Systemal pressure and fluid volumes required to achieve sodium balance (prevention of salt-sensitivity), and to increase the efficiency of cardiovascular dynamics by promoting the growth of the heart and vessels, and sensitizing blood vessels to vasoconstrictor agents (slowest actions of angiotensin). Act

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Immunohistochemistry of Angiotensin median eminence and the neurohypophysis. Recent studies have shown that in spite of using the same antigen molecule for immunization as well as for affinity purification, different staining pattern are obtained, suggesting that the different carrier proteins forced the production of different antib

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Renin-Angiotensin System: Plasma Versus Tissuesro)renin receptors located on the cell membrane, combined with the fact that angiotensin-converting enzyme (ACE) also is a membrane-associated enzyme, favours angiotensin generation on the cell surface. Although renin has also been demonstrated intracellularly, intracellular angiotensin generation i