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Titlebook: Analysis of Genetic Association Studies; Gang Zheng,Yaning Yang,Robert C. Elston Book 2012 Springer Science+Business Media, LLC 2012 Assoc

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发表于 2025-3-21 17:11:07 | 显示全部楼层 |阅读模式
期刊全称Analysis of Genetic Association Studies
影响因子2023Gang Zheng,Yaning Yang,Robert C. Elston
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发行地址Authors are leading researchers and professors in the fields of Epidemiology and Biostatistics.This book presents crucial analysis and information for students, researchers, and professionals.Illustra
学科分类Statistics for Biology and Health
图书封面Titlebook: Analysis of Genetic Association Studies; Gang Zheng,Yaning Yang,Robert C. Elston Book 2012 Springer Science+Business Media, LLC 2012 Assoc
影响因子.Analysis of Genetic Association Studies .is both a graduate level textbook in statistical genetics and genetic epidemiology, and a reference book for the analysis of genetic association studies. Students, researchers, and professionals will find the topics introduced in .Analysis of Genetic Association Studies. particularly relevant.  The book is applicable to the study of statistics, biostatistics, genetics and genetic epidemiology.  . .In addition to providing derivations, the book uses real examples and simulations to illustrate step-by-step applications.  Introductory chapters on probability and genetic epidemiology terminology provide the reader with necessary background knowledge.  The organization of this work allows for both casual reference and close study.  .
Pindex Book 2012
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Bayes Factors for Case-Control Association Studieslikelihood estimate of the odds ratio for the genetic effect. In this chapter, the underlying genetic model is assumed to be known (either a recessive, additive or dominant model). How to code the genetic effect in a Bayesian analysis is discussed. The result may depend on how the genetic effect is
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Haplotype Analysis for Case-Control Dataotype frequencies. Haplotype disequilibrium, testing for linkage disequilibrium (LD), haplotype blocks and tagging SNPs are discussed. Two types of tests are considered. The first is haplotype-based association analysis, including the likelihood ratio test, regression method, and haplotype similarit
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Gene-Gene Interactions The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied. Different test statistics for the two-locus interaction model are discussed. Their relation to contrasting log-odds ratios and contrasting LD m
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Gene-Environment Interactionsnvironmental factor effect, and the gene-environment interaction are given. More general cases for gene and environmental factors are briefly discussed. Three common tests for gene-environment interaction are studied, including the Score test, the likelihood ratio test (LRT) and the Wald test. Examp
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