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Titlebook: Analgesia; Christoph Stein Book 2007 Springer-Verlag Berlin Heidelberg 2007 Arthritis.Cancer.Cannabinoid.Headache.Inflammation.Opioid.Pain

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发表于 2025-3-21 17:57:11 | 显示全部楼层 |阅读模式
期刊全称Analgesia
影响因子2023Christoph Stein
视频video
发行地址Includes supplementary material:
学科分类Handbook of Experimental Pharmacology
图书封面Titlebook: Analgesia;  Christoph Stein Book 2007 Springer-Verlag Berlin Heidelberg 2007 Arthritis.Cancer.Cannabinoid.Headache.Inflammation.Opioid.Pain
影响因子Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular method
Pindex Book 2007
The information of publication is updating

书目名称Analgesia影响因子(影响力)




书目名称Analgesia影响因子(影响力)学科排名




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书目名称Analgesia被引频次学科排名




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发表于 2025-3-21 21:53:17 | 显示全部楼层
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https://doi.org/10.1007/978-3-662-33072-2kinins have a pathophysiological role in nociception. Clinical studies with non-peptide pharmacological antagonists are now in progress to determine if blocking the action of these peptides might have utility in the treatment of pain.
发表于 2025-3-22 08:19:25 | 显示全部楼层
https://doi.org/10.1007/978-3-642-97695-7of P2X. receptors may be useful for relieving inflammatory and neuropathic pain. More recently, data have begun to emerge implicating P2X., P2X. and P2Y receptors in aspects of pain transmission. Both P1 and P2 receptors may represent novel targets for pain relief.
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发表于 2025-3-22 13:25:58 | 显示全部楼层
Neuropeptide and Kinin Antagonistskinins have a pathophysiological role in nociception. Clinical studies with non-peptide pharmacological antagonists are now in progress to determine if blocking the action of these peptides might have utility in the treatment of pain.
发表于 2025-3-22 17:26:31 | 显示全部楼层
Adenosine and ATP Receptorsof P2X. receptors may be useful for relieving inflammatory and neuropathic pain. More recently, data have begun to emerge implicating P2X., P2X. and P2Y receptors in aspects of pain transmission. Both P1 and P2 receptors may represent novel targets for pain relief.
发表于 2025-3-23 00:28:56 | 显示全部楼层
Opioidsg, cAMP inhibition, Ca. channel inhibition) have been described. The differential regulation of effectors, preclinical pharmacology, clinical applications, and side effects will be reviewed in this chapter.
发表于 2025-3-23 03:34:04 | 显示全部楼层
Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamolese drugs with particular emphasis on their rational use based on the diverse pharmacokinetic characteristics and adverse drug reaction profiles. Referring to the current debate, potential mechanisms underlying cardiovascular side effects associated with long-term use of COX inhibitors are discussed.
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