Titlebook: An Information Technology Framework for Predictive, Preventive and Personalised Medicine; A Use-Case with Hepa Leonard Berliner,Heinz U. Le

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Personalized Chemotherapy for Hepatocellular Carcinoma,volves a number of alterations that are genetic and epigenetic such as the activation of cellular oncogenes and the inactivation of tumor suppressor genes. Systemic therapy with single-agent or combination chemotherapy has been studied extensively. However, cytotoxic chemotherapy traditionally has b

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Surgical Treatment for Hepatocellular Carcinoma,ment of choice for patients with compromised liver function (Child-Pugh B/C). The clinical parameters identified in this Chapter will be used to generate Digital Patient Models (DPMs) to facilitate diagnosis, prognosis, and treatment selection, i.e. Model Guided Therapy (MGT). The following have bee

CREST

Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies,s the largest clinical experience and will serve as the prototype for understanding the principles, mechanisms, and methods that have been developed for the treatment of HCC. Ablation is performed with a minimally invasive approach—the effect is delivered interstitially and intratumorally via a devi

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Minimally Invasive Therapies for Hepatocellular Cancer: Catheter-Directed Therapies, therapy and may be a more effective treatment for HCC. Further study will be needed to determine the effectiveness of combining RFA and TACE, and in which order. The combination of TACE with antiangiogenic agents, such as sorafenib, is under investigation as well. The use of sorafenib may curtail t

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Radiation Oncology in the Treatment of Hepatocellular Carcinoma,n to be an effective alternative to other ablative procedures in nonsurgical candidates with tumors up to 6 cm in size, including HCC in patients with cirrhosis. Radioembolization involves catheter-based infusion of radioactive particles (such as Yttrium-90-labeled microspheres) targeted at the hepa

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Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocion, and treatment of HCC. Through the development of an ITS-PM, it may be possible to provide and validate a new methodology for Evidence-Based Medicine utilizing model theory, i.e. Model-Based Medical Evidence (MBME). The information processed in the development of this book was used to reinforce

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