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Titlebook: Amine Oxidases and Their Impact on Neurobiology; Proceedings of the 4 Peter Riederer,Moussa B. H. Youdim Conference proceedings 1990 Spring

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MAO activity, metabolism and anticonvulsant activity of milacemide in rats and micesuggested that the anticonvulsant activity of milacemide might be related to MAO-B- mediated glycine formation, brain and liver MAO-A and-B activities and the urinary metabolic pattern of milacemide were determined in the same mice and rat strains. Similar brain and liver MAO activities were found i
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Amine Oxidases and Their Impact on Neurobiology978-3-7091-9113-2Series ISSN 0303-6995
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0303-6995 Overview: 978-3-211-82239-5978-3-7091-9113-2Series ISSN 0303-6995
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[3H] Harman labels selectively and with high affinity the active site of monoamine oxidase (EC 1.4.3f the CNS of the 3 species [.H]harman binding exhibits the same pharmacological profile in displacement studies. A detailed analysis reveals a high specificity for MAO-A..Furthermore, we applied [.H]harman binding to quantify the MAO-A content in 6 CNS regions of each species as well as in 6 visceral organs of the rat.
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https://doi.org/10.1007/978-3-662-67441-3Immunofluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of MAO-A and MAO-B revealed that only about 10% of the melanin-containing neurons are positive for MAO-A, while they are substantially free of MAO-B.
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Problemstellung und ZielsetzungIn vivo voltammetric analyses on the action of the monoamine oxidase inhibitors pargyline, deprenyl, and clorgyline on dopamine and serotonin metabolism in rat brain showed strain and regional differences depending on the compound under study.
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Immuno-fluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of Immunofluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of MAO-A and MAO-B revealed that only about 10% of the melanin-containing neurons are positive for MAO-A, while they are substantially free of MAO-B.
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