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Titlebook: Alternating Electric Fields Therapy in Oncology; A Practical Guide to Eric T. Wong Book 2016 Springer International Publishing Switzerland

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发表于 2025-3-21 19:46:45 | 显示全部楼层 |阅读模式
期刊全称Alternating Electric Fields Therapy in Oncology
期刊简称A Practical Guide to
影响因子2023Eric T. Wong
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发行地址A complete overview of alternating electric fields therapy in clinical practice.Covers the therapeutic application for a variety of malignancies.Written for a broad audience that includes clinicians,
图书封面Titlebook: Alternating Electric Fields Therapy in Oncology; A Practical Guide to Eric T. Wong Book 2016 Springer International Publishing Switzerland
影响因子.This concise text provides acomplete overview of alternating electric fields therapy -- also known as tumortreating fields -- for glioblastoma and other types of solid tumormalignancies. Readers are given a fundamental understanding of this novelanti-cancer treatment modality by learning from clinical trial data as well asthe physical and cell biology effects on tumor cells when alternating electricfields are applied both .in vitro. and .in vivo....Chapters illustrate the physicsbehind electric field propagation in space and other media. This isfollowed by a review of our current understanding of the electric field effectson dividing cells - including the disruption of cytokinesis, proper chromosomesegregation and activation on the cell surface chaperons that induceimmunogenic cell death. Data from phase III trials for the treatment ofrecurrent and newly diagnosed glioblastomas are included, as well as some ofthe ancillary .post hoc. analyses thatwere performed by variousinvestigators. The remainder of the chapter covers other solid tumormalignancies, including non-small cell lung cancer, pancreatic cancer andovarian cancer, as this treatment modality is being applied to systemicm
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发表于 2025-3-21 22:02:13 | 显示全部楼层
Fundamental Physics of Tumor Treating Fields,. Recently, the anticancer Tumor Treating Fields (TTFields), which are alternating electric fields applied according to the principles of Maxwell’s equations of electromagnetism, has made available a novel method of treating patients with glioblastomas, brain metastases, and certain systemic maligna
发表于 2025-3-22 03:21:28 | 显示全部楼层
Biophysical Effects of Tumor Treating Fields, theoretical investigations lead to numerous cell characterization and manipulation techniques which were translated into clinical applications. Low-frequency alternating current (AC) fields are employed for nerve and muscle stimulation, while high-frequency fields find medical relevance in tissue h
发表于 2025-3-22 07:26:34 | 显示全部楼层
Computer Simulation of Tumor Treating Fields,ents. TTFields are alternating electric fields at 200 kHz continuously delivered by the Optune device to the scalp of patients. Preclinical experiments have shown that they interfere with dividing cancer cells as they undergo metaphase-to-anaphase transition in mitosis and, specifically, they disrup
发表于 2025-3-22 09:49:22 | 显示全部楼层
Response Pattern and Modeling of Tumor Treating Fields,. The Optune device represents an innovative treatment option for patients with recurrent GBM, which utilizes alternating electric fields at an intermediate frequency of 200 kHz, or Tumor Treating Fields (TTFields), to selectively kill or arrest the growth of rapidly dividing cells. Approximately 15
发表于 2025-3-22 14:47:08 | 显示全部楼层
Clinical Efficacy of Tumor Treating Fields for Recurrent Glioblastoma, criteria but the extent of the tumor is much larger than that can be seen on neuroimaging. Patient prognosis is poor and survival is short. The Optune device is an FDA-approved treatment for recurrent glioblastoma and it uses Tumor Treating Fields (TTFields) to disrupt tumor cells as they undergo m
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发表于 2025-3-23 00:22:57 | 显示全部楼层
Tumor Treating Fields Therapy for Newly Diagnosed Glioblastoma, within the tumor microenvironment. These inter-tumoral and intra-tumoral heterogeneities are what make glioblastomas so difficult to treat in patients. As the tumor progresses over time, it accumulates more alterations and co-opts normal physiological processes for growth and proliferation as well
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发表于 2025-3-23 07:08:45 | 显示全部楼层
Future Directions for Tumor Treating Fields,d glioblastoma since receiving FDA approvals in 2011 and 2015, respectively. Where this treatment modality goes from here is currently a subject of intensive clinical investigations. For glioblastoma, TTFields are being combined with stereotactic radiosurgery, hypofractionated radiation, bevacizumab
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