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Titlebook: Alternate Programmed Cell Death Signaling in Antiviral Host Defense; Edward S. Mocarski,Pratyusha Mandal Book 2023 Springer Nature Switzer

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期刊全称Alternate Programmed Cell Death Signaling in Antiviral Host Defense
影响因子2023Edward S. Mocarski,Pratyusha Mandal
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发行地址Provides a comprehensive perspective on programmed cell death in antiviral immune response.Focuses on cell autonomous cell death pathways in mammals.Sheds new light on additional features of the signa
学科分类Current Topics in Microbiology and Immunology
图书封面Titlebook: Alternate Programmed Cell Death Signaling in Antiviral Host Defense;  Edward S. Mocarski,Pratyusha Mandal Book 2023 Springer Nature Switzer
影响因子.This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system...Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus...Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV)where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its
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ZBP1/DAI-Dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis,but a subset of strains infects other avian as well as mammalian species, including humans. In aquatic birds, infection is largely restricted to the gastrointestinal tract and spread is through feces, while in humans and other mammals, respiratory epithelial cells are the primary sites supporting pr
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Cell Killing by Reovirus: Mechanisms and Consequences,yocytes contributes to the pathogenesis of reovirus-induced encephalitis and myocarditis in a newborn mouse model. Thus, reovirus-induced cell death has been used to investigate the basis of viral disease. Depending on the cell type, infection of host cells by reovirus results in one of two forms of
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Seth Goldstein MD, MPhil,F. Dylan Stewart MDtogether with other released components. Pyroptosis, like other forms of programmed cell death, helps eliminate infected cells and thereby restricts the replicative niche, undermining survival and proliferation of intracellular pathogens. This includes viruses as well as bacteria, where ample eviden
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