Titlebook: Alpha-1 Antitrypsin; Methods and Protocol Cynthia L. Bristow Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive lic

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书目名称Alpha-1 Antitrypsin影响因子(影响力)




书目名称Alpha-1 Antitrypsin影响因子(影响力)学科排名




书目名称Alpha-1 Antitrypsin网络公开度




书目名称Alpha-1 Antitrypsin网络公开度学科排名




书目名称Alpha-1 Antitrypsin被引频次




书目名称Alpha-1 Antitrypsin被引频次学科排名




书目名称Alpha-1 Antitrypsin年度引用




书目名称Alpha-1 Antitrypsin年度引用学科排名




书目名称Alpha-1 Antitrypsin读者反馈




书目名称Alpha-1 Antitrypsin读者反馈学科排名

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Approaches to Therapeutic Gene Editing in Alpha-1 Antitrypsin Deficiencyion of double-strand breaks (DSBs) and subsequent creation of insertions and deletions (indels) by DSB repair, homology-directed repair (HDR) targeted to the mutation site, base editing, prime editing, and alternatively targeted knock-in techniques. Each approach will be discussed and a brief summar

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Manipulation of Proteostasis Networks in Transgenic ZAAT Zebrafish via CRISPR–Cas9 Gene Editingfish α1-antitrypsin deficiency (AATD) model displays an unusual phenotype, in that it lacks the hepatic accumulation of the misfolding Z α1-antitrypsin (ZAAT) evident in human and mouse models. Here we describe the application of the CRISPR–Cas9 system to generate mutant zebrafish with defects in ke

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Alpha-1-Antitrypsin (A1AT) Proteotyping by LC-MS/MSrmination of specific allelic variants by phenotyping (isoelectric focusing (IEF) gel electrophoresis) and/or allele-specific genotyping. Various phenotyping and genotyping methodologies are available, and each has their own advantages and disadvantages. As an alternative, mass spectrometry is emerg

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