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Titlebook: Airway Mucus: Basic Mechanisms and Clinical Perspectives; Duncan F. Rogers,Michael I. Lethem Book 1997 Springer Basel AG 1997 Atmen.Respir

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Mechanisms Controlling Airway Ciliary Activity,ithout mucociliary clearance, the airways would remain exposed to infectious agents or reactive substances — a situation that often results in chronic obstructive lung disease. The conditions that predispose mucociliary clearance to failure are not well established, but if therapies are to be design
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Goblet Cells: Physiology and Pharmacology,each day. These mucus—particulate complexes are propelled by incessantly beating cilia to the glottis over the luminal surface of epithelium lining the airways, and are cleared from the airways by swallowing. The principal component of mucus is the high molecular weight glycoconjugate (HMWG) mucin,
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,Mucus—Bacteria Interactions,. The surface area required for gas exchange is provided by large numbers of alveoli supplied by repeated branching of the bronchial tree. Through these blind-ending airways pass 1-2 x l0. 1 of air per 24 h. The respiratory mucosa is therefore continually exposed to a variety of noxious agents which
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Experimental Induction of Goblet Cell Hyperplasia , ,ral human airway conditions, such as chronic bronchitis, asthma, cystic fibrosis and bronchiectasis have mucus-hypersecretion as a common feature [.-.]. The major sources of airway mucus are (1) luminal mucosubstance present on surface epithelium whose cellular source is presently unclear [.-.], (2)
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Mucus Hypersecretion and Its Role in the Airway Obstruction of Asthma and Chronic Obstructive Pulmoof submucosal tissue swollen with oedema or engorged blood vessels, collapse of the airway walls under a pressure gradient and accumulation of mucus. Only in the last of these, the subject of this chapter, is the obstruction situated within the airway lumen itself; the remainder result from processe
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