Titlebook: Aging at the Molecular Level; Thomas Zglinicki (Professor of Cellular Gerontolog Book 2003 Springer Science+Business Media Dordrecht 2003

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Aging Rate, Mitochondrial Free Radical Production, and Constitutive Sensitivity to Lipid Peroxidati reach 122 years whereas rats only last at best 4 years? Fortunately, some answers to that fundamental question are emerging in recent years. Many different “theories” of aging have been proposed in the past, mainly because gerontological knowledge was seriously limited. The mitochondrial oxygen rad

lethargy

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Mitochondria and Aging,es of membrane-bound enzymes (complexes I–IV) and mobile electron carriers (ubiquinone and cytochrome . to molecular oxygen resulting in the formation of water [1]. The chemical energy involved in these electron transfers is stored as a transmembrane chemical gradient established by the translocatio

Fibrillation

adhesive

BROOK

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Non-oxidative Modification of DNA and Proteins,potential sources of macromolecular instability both oxidative and non-oxidative. In recent years much attention has been given to the role of reactive oxygen species (ROS) as potential sources macromolecular alteration reflecting the popularity of the free-radical theory of aging. In an attempt to

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Transcriptional and Translational Dysregulation During Aging, pattern of gene expression must be maintained for the normal functioning of cells and for the survival of the organism. Since aging is considered to be a result of failure of maintenance at all levels, attempts have been made to look for an age-related drifting-away of cells in terms of changes in

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Metabolic Regulation of Gene Silencing and Life Span, eukaryotes most genes are “silent,” meaning that they are transcriptionally inert and that this state is heritable. Many changes in gene expression occur during cellular senescence and organismal aging [1, 2]. Although most of these are considered to be downstream effects rather than causes of agin

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