Titlebook: Aging Mechanisms II; Longevity, Metabolis Nozomu Mori Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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To G0 or Not to G0: Cell Cycle Paradox in Senescence and Brain Agingtic control mechanisms in the aged brain. Here we highlight an emerging paradigm shift regarding senescence and discuss the potential physiological relevance of post-mitotic neuronal senescence in aging.

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Understanding the Functions of Longevity Genes in ignaling pathway plays a critical role in regulating organismal physiology upon oxidative stress and longevity. More recently, an emerging target is epigenetic mechanisms, which appear to control longevity with novel pathways.

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NAD+ Metabolism in Agingogies and extend health span. Early clinical trial results suggest that NR and NMN are safe and bioavailable in humans and certain effectiveness has been demonstrated. Thus, NAD. metabolism is an exciting field whose modulation can provide beneficial effects and may improve human health.

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978-981-16-7979-7The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor

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Nozomu MoriSummarizes the latest research on aging biology from leading laboratories.Discusses biological mechanisms of aging from molecular and cellular levels to physiological and systemic levels.Covers import

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,Das Leben vor der Dichterzeit (1825–1865),ging, i.e., the mutation or genome instability theory, the free radical or oxidative stress theory, the mitochondrial theory, the error catastrophe theory, the altered protein or protein homeostasis or proteostasis theory, the dysdifferentiation or epigenetic theory, and the hyperfunction theory, ad

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