| 期刊全称 | Agammaglobulinemia | | 影响因子2023 | Alessandro Plebani,Vassilios Lougaris | | 视频video | | | 发行地址 | Provides a comprehensive and detailed overview of a rare form of primary immunodeficiency.Explains the genetic basis of the disease, with an overview of animal models.Describes advanced and experiment | | 学科分类 | Rare Diseases of the Immune System | | 图书封面 |  | | 影响因子 | .This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton’s tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia. Patients’ management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are discussed. The book’s closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.. | | Pindex | Book 2015 |
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发表于 2025-3-21 18:35:43
