Titlebook: Advances in Tumor Immunology and Immunotherapy; Joseph D. Rosenblatt,Eckhard R. Podack,Augusto Och Book 2014 Springer Science+Business Med

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T Cell Co-regulatory Signals and Their Role in Cancer Therapy can modify this original activating signal. T cell co-regulation is provided by receptors on the T cell surface membrane. Inhibitory signals are provided by CTLA4 or PD-1, while co-stimulation is provided by CD28, 4-1BB, OX40, or GITR. These signals are being studied in the laboratory and at the cl

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https://doi.org/10.1007/978-1-349-11877-9nd some antagonistic, between mechanisms that can impact on the efficacy of therapy. An improved understanding of the relative importance of each mechanism, and how these mechanisms interact in various clinical scenarios, is vital if we are to make a highly valuable approach to cancer therapy even better.

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Book 2014em. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. .Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppres

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2199-2584 essive mechanisms, and emerging strategies for manipulation .Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechan

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Employing T Cell Homeostasis as an Antitumor Strategyn place for compensatory expansion after depletion, an effect called homeostasis-driven T cell expansion, has been exploited in both preclinical models as well as clinical therapies. This chapter examines both.

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Activation of NK Cell Responses and Immunotherapy of Cancernd some antagonistic, between mechanisms that can impact on the efficacy of therapy. An improved understanding of the relative importance of each mechanism, and how these mechanisms interact in various clinical scenarios, is vital if we are to make a highly valuable approach to cancer therapy even better.