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Titlebook: Advances in Statistical Methods for the Health Sciences; Applications to Canc Jean-Louis Auget,N. Balakrishnan,Geert Molenberghs Book 2007

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Wu-Sheng Wang,Zizun Li,Anmin Tang both methods, the mixed PCM being more conservative than the ASM. Although remaining a bit underpowered, the mixed PCM displayed higher power than the ASM for both sequential tests. Both methods allowed substantial reductions in average sample numbers as compared with fixed sample designs. Overlapp
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Hans Dieter Dahmen,Siegmund Brandtng the two ratings at all possible cutpoints, there are (.−1)(.−1) possible (2×2) tables. For each of these (2×2) tables, we estimate the Kappa coefficient for dichotomous ratings. The largest estimated Kappa coefficients suggest the cutpoints for the two ratings where agreement is the highest and w
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Where Next for Evidence Synthesis of Prognostic Marker Studies? Improving the Quality and Reporting Unfortunately, within any given disease area, the wealth of conflicting and heterogeneous evidence makes it difficult for the clinician to ascertain the overall evidence about specific markers and how to use them in practice. The application of formal methods (e.g., a systematic review and meta-anal
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