Titlebook: Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions; Current and Future T Neil H. Shear,Roni P. Dodiuk-Gad Book 2019 S

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Pyruvate Dehydrogenase Deficiency Disorders most commonly with penicillins and NSAIDs. The pathogenic mechanism of urticarial reactions can be divided into immunological (Type I, IgE-mediated or Type III complement activation) and non-immunological (degranulation of mast cells).

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Gerard B. Odell,Henry S. Schuttaintaining QoL. This chapter addresses dAEs induced by cytotoxic and targeted therapies, radiotherapy, stem cell transplantation, immunotherapies, and CAR-T cell therapy. Proposed underling mechanisms and recommended treatment approaches for these dAEs are presented.

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Gerard B. Odell,Henry S. Schuttance of offending drug classes is different than in adults—anti-infectives make the majority, followed by antipyretics and antiepileptics. In this chapter, unique CADR features in the pediatric population are discussed, and a morphologic approach, based on simple and complex/severe eruptions, is suggested.

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F. Sharp MD,D.-Z. Liu,X. Zhan,B. P. Ander a drug since the severity of skin manifestation does not necessarily mirror the severity of the systemic involvement. This chapter aims to provide a practical approach to a patient with a suspected drug eruption.

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