期刊全称 | Advances in DNA Damage and Repair | 期刊简称 | Oxygen Radical Effec | 影响因子2023 | Miral Dizdaroglu,Ali Esat Karakaya | 视频video | | 学科分类 | NATO Science Series A: | 图书封面 |  | 影响因子 | Damage to DNA by both exogenous and endogenous sources isincreasingly regarded as highly important in the initiation andprogression of cancer and in the occurance of other pathologicalevents. DNA damage caused by reactive oxygen-derived species, alsocalled oxidative DNA damage, is most the frequent type encountered byaerobic cells. Mechanistic studies of carcinogenesis indicate animportant role of this type of damage to DNA. There is also strongevidence to support the role of oxidative DNA damage in the agingprocess. DNA damage is opposed .in vivo. by repair systems. If notrepaired, DNA damage may lead to detrimental biological consequences.Therefore, the repair of DNA damage is regarded as one of theessential events in all life forms. In recent years the field of DNArepair has flourished due to new findings on DNA repair mechanisms andthe molecular basis of cancer. A detailed knowledge of mechanisms ofDNA damage and repair, and how individual repair enzymes function maylead to manipulation of DNA repair in cells and ultimately to anincrease of the resistence of human cells to DNA-damaging agents. Thisvolume covers the most recent devlopments in this research field andcontains cont | Pindex | Book 1999 |
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