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Titlebook: Admixture Dynamics, Natural Selection and Diseases in Admixed Populations; Wenfei Jin Book 2015 Springer Science+Business Media Dordrecht

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发表于 2025-3-21 17:22:42 | 显示全部楼层 |阅读模式
期刊全称Admixture Dynamics, Natural Selection and Diseases in Admixed Populations
影响因子2023Wenfei Jin
视频video
发行地址Nominated as an outstanding Ph.D. Thesis by Chinese Academy of Sciences, China.Illustrating signals of natural selection in African American ?.Advancing the understanding on the recent population admi
学科分类Springer Theses
图书封面Titlebook: Admixture Dynamics, Natural Selection and Diseases in Admixed Populations;  Wenfei Jin Book 2015 Springer Science+Business Media Dordrecht
影响因子.In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications..
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发表于 2025-3-21 20:41:00 | 显示全部楼层
Genome-Wide Search for Signatures of Natural Selection in African Americans,ke, Datenbanken, neue Programmiersprachen und der Trend zur Objektorientierung haben sich etabliert. Die meisten Unternehmen sind heute aber immer noch mit ihrer Informationsverarbeitung abhängig von Applikationen, die die Gedankenwelt und Technologie zum Zeitpunkt ihrer Konzeption vor teilweise meh
发表于 2025-3-22 03:14:22 | 显示全部楼层
发表于 2025-3-22 04:42:10 | 显示全部楼层
https://doi.org/10.1007/978-981-33-6742-5dentify the genetic variation underlying complex diseases. With the advance of the genomic genotyping and sequencing technology, the statistical powers for identifying genetic variants underlying human disease have significantly improved, using either associate study or admixture mapping.
发表于 2025-3-22 11:32:52 | 显示全部楼层
Book 2015 role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications..
发表于 2025-3-22 13:06:44 | 显示全部楼层
2190-5053 ?.Advancing the understanding on the recent population admi.In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population historie
发表于 2025-3-22 19:01:07 | 显示全部楼层
https://doi.org/10.1007/978-981-33-6742-5 the admixture dynamics of African Americans among several putative scenarios. On the contrary, the admixture dynamics of Mexicans was more likely to be explained by a gradual admixture model in which Mexicans continuously received gene flow from both European and Amerindian parental populations for about 24 generations.
发表于 2025-3-23 01:02:01 | 显示全部楼层
https://doi.org/10.1007/978-981-33-6742-5 proportion and admixture time in the two models are identical. In addition, we found the peak of association signatures in HI model was much narrower and sharper than that in GA model, indicating that the identification of putative causal allele in HI model is more efficient than that in GA model.
发表于 2025-3-23 02:05:25 | 显示全部楼层
https://doi.org/10.1007/978-981-33-6742-5 are subject to both strong positive and strong purifying selections, simultaneously; while genes only underlying monogenic diseases and complex diseases were only subjected to strong purifying selection and strong positive selection, respectively.
发表于 2025-3-23 08:54:31 | 显示全部楼层
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