Titlebook: Acute Leukemias; Pharmacokinetics and W. Hiddemann,T. Büchner,M. Andreeff Conference proceedings 1992 Springer-Verlag Berlin Heidelberg 199

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Marihuana-Gebrauch und soziale Kontrolle,Identification of anthracyclines which are able to overcome multidrug resistance would be a major step towards to improving antineoplastic chemotherapy.

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Jürgen Christmann,Merle ChristmannAcute leukemia has become a curable disease, although intensive therapy is required to obtain a cure [1, 2]. Therefore, a high degree of myelosuppression and resultant infectious complication are the major obstacles in its treatment.

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Dirk Schmidt,Sebastian Heilmannf these patients are expected to be cured of their disease [1]. Among patients with acute myeloid leukemia (AML) and adults with acute lymphocytic leukemia, sustained complete remissions are achieved in only 20%–40% of cases [2, 3]. Remission rates in patients relapsing from a complete remission are

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https://doi.org/10.1007/978-3-642-99838-6 are cross-resistant to structurally different natural occurring drugs. One form of MDR is related to a reduction of drug accumulation in the resistant cells [7]. The drug efflux mechanism seems to be mediated by a 170 kDa plasma membrane glycoprotein which acts as an ATP-dependent drug efflux pump

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