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Titlebook: Activators and Inhibitors of Complement; Robert B. Sim (Medical Research Council Scientific Book 1993 Springer Science+Business Media Dord

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Problemstellung und Zielsetzung, and involved in binding to antigen — the Fab (fragment antigen binding) arms of the molecule. The third unit, Fc (fragment crystalline), is generally involved in interaction with effector systems such as complement. The two identical heavy (H) chains of the molecule span Fab and Fc regions and the
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Praktische Anwendung des Instrumentariums,ourth component of complement was reported in 1926 [1]. These early experiments showed that ammonia was an effective inhibitor only at pH values greater than 8, at which the NH., nucleophilic, form will be present. Inhibition of C4 by ammonia contributed to the development of ideas on the complement
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Problemstellung und Zielsetzung,es of the complement system. Around the turn of the century ‘complement’ was recognized as a heat labile factor contributing to the bactericidal activity in serum [1, 2]. At that time it was discovered that certain snake venoms, most effectively that of cobra, destroyed this bactericidal effect [3],
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Brigitte Winkler,Stefan Dörr,Ulfried Kleblteins, (4) as models to study the conformational aspects and folding rules of proteins, (5) as immunogens to produce antibodies of predetermined specificity with possible use as vaccines, and (6) as tools to study the details of antigen-antibody interactions (for details seeref. [1–11]).
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Book 1993 the circulation and extracellular spaces. Thesystem is activated by a wide range of targets, and activation leadsto the production of opsonins, chemotaxis of granulocytes, cell lysisand other biological activities. Inappropriate overactivation of thesystem contributes to inflammatory tissue damage
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