| 书目名称 | Zinc Finger Proteins | | 副标题 | From Atomic Contact | | 编辑 | Shiro Iuchi,Natalie Kuldell | | 视频video | | | 概述 | The authors include a Nobel Prize laureate, several founders of zinc finger research and the related research fields, and well-known, cutting edge scientists.Includes supplementary material: | | 丛书名称 | Molecular Biology Intelligence Unit | | 描述 | In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING | | 出版日期 | Book 2005 | | 关键词 | DNA; RNA; gene expression; genes; protein family; proteins; ribosomal RNA; signal transduction; transcriptio | | 版次 | 1 | | doi | https://doi.org/10.1007/b139055 | | isbn_softcover | 978-1-4419-3434-5 | | isbn_ebook | 978-0-387-27421-8Series ISSN 1431-0414 | | issn_series | 1431-0414 | | copyright | Springer-Verlag US 2005 |
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发表于 2025-3-21 16:12:17
