Titlebook: West Nile Virus; Methods and Protocol Tonya M. Colpitts Book 2016 Springer Science+Business Media New York 2016 West Nile Virus infection.i

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A Brief Review of West Nile Virus Biology,NV is an arthropod-transmitted virus that mainly affects birds but humans become infected as incidental dead-end hosts which can cause outbreaks in naïve populations. The main vectors of WNV are mosquitoes of the genus ., which preferentially feed on birds. As in many other arboviruses, the characte

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Lessons from the Murine Models of West Nile Virus Infection,r parts of the world over the past decade. Up to 50 % of WNV convalescent patients were reported to have long-term neurological sequelae or chronic kidney diseases. However, there are neither antiviral drugs nor vaccines available for humans. The underlying mechanism of the long-term sequelae is not

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Exploration of West Nile Virus Infection in Mouse Models,ential cells can produce antiviral immune responses, the blood leukocytes are required to contain virus spread. However, infiltrating leukocytes may also contribute to immunopathology if they overreact. Thus analyses of WNV infectivity and leukocyte numbers in the CNS are critical for understanding

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,In Vitro and In Vivo Blood–Brain Barrier Models to Study West Nile Virus Pathogenesis, molecular and cellular flux between the two. It plays a critical role in the maintenance of brain hemostasis. The BBB restricts the entry of pathogens into the brain, and thus its permeability is a critical factor that determines their central effects. Once the permeability of BBB is compromised, i