Titlebook: Water Soluble Vitamins; Clinical Research an Olaf Stanger Book 2012 Springer Science+Business Media B.V. 2012 Biochemistry.Health.Lifestyle

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Genetic Aspects of Folate Metabolism,n cells carry out folate dependent reactions. In recent years, low folate status has been linked to risk of numerous adverse health conditions throughout life from birth defects and complications of pregnancy to cardiovascular disease, cancer and cognitive dysfunction in the elderly. In many instanc

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Enzymatic and Non-enzymatic Antioxidative Effects of Folic Acid and Its Reduced Derivates,ve methods and parameters currently in use. As the role of folate deficiency in congenital defects, e.g. in cardiovascular and neurodegenerative diseases, and in carcinogenesis has become better understood, folate has been recognized as having great potential to prevent these many disorders through

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Folate-Linked Drugs for the Treatment of Cancer and Inflammatory Diseases,s (i.e. purines, thymidine) and several amino acids. In general, two functionally different systems mediate the cellular uptake of folate: (1) the reduced folate carrier (RFC, Kd ∼ 10–6 M), an anion transporter that delivers folates across the plasma membrane in a bidirectional fashion, and (2) the

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Folate in Skin Cancer Prevention,tection against exposure to sunlight, a major source of skin damage where the UV radiation (UVR) component functions as a complete carcinogen. Melanin pigmentation and the evolution of dark skin is an adaptive protective mechanism against high levels of UVR exposure. Recently, the hypothesis that sk

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Thiamin(e): The Spark of Life,und that it was not an amine. It is still spelled with and without the “e” depending on the text. This chapter provides a brief historical review of the association of thiamin with the ancient scourge of beriberi. It emphasizes that beriberi is the model for high calorie malnutrition because of its

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